Mean Corpuscular Haemoglobin Concentration (MCHC)

Mean Corpuscular Haemoglobin Concentration (MCHC)

April 28, 2022

Mean Corpuscular Haemoglobin Concentration (MCHC)

What Is Mean Corpuscular Hemoglobin Concentration (MCHC)?

MCHC stands for mean corpuscular haemoglobin concentration. It’s a measure of the average concentration of hemoglobin inside a single red blood cell. MCHC is commonly ordered as part of a complete blood count (CBC) panel.

Why is this analysis important?

In many cases, when haemoglobin production is reduced, the production of red blood cells is likewise reduced. However, in some cases, haemoglobin production can be reduced, while red blood cell production can increase. This can help differentiate specific conditions from one another.

What are some of the causes of high Corpuscular Hemoglobin Concentration (MCHC) levels?

A high mean corpuscular hemoglobin concentration (MCHC) can cause hyperchromia, or darker colored red blood cells:

  • Hemolytic Anemia

  • Vitamin B12 and Folate Deficiency

  • Hereditary Spherocytosis

What are some of the causes of low Corpuscular Hemoglobin Concentration (MCHC) levels?

A low mean corpuscular haemoglobin concentration (MCHC) can cause hypochromia, or paler red blood cells. it is linked to multiple health causes:

  • Iron deficiency

  • Anaemia linked to a chronic disease

  • Thalassemia

  • Sideroblastic Anemia